Brands Names: Provigil
Price Range: $0.82 – $1.76
Dosage: 100mg / 200mg
Provigil belongs to the class of drugs called “smart drugs” or psychostimulants. These medications can significantly improve concentration, cognitive skills, and also have a stimulating effect on the nervous system, allowing to increase patients’ efficiency and reduce the need for sleep.
The active ingredient of the drug (modafinil) is a psychostimulant produced in the 1970s by Cephalon Inc. and intended to treat narcolepsy. Provigil was approved by the Food and Drug Administration (FDA) in 1998, and still is an excellent alternative to caffeine, amphetamine, and other popular stimulants of synthetic origin.
Large-scale clinical trials demonstrated that Provigil increases the level of serotonin in the anterior cortex and amygdala and stimulates an increased ejection from the synaptic gaps of dopamine, norepinephrine, and other monoamines. Under the influence of the drug, the hypothalamus intensively produces histamine and causes the activation of alpha-1 receptors.
What does Provigil do?
One of the most important and pronounced effects is an increase in concentration, cognitive functions, and the assimilation and accommodation of knowledge. Although Provigil is not an antidepressant and does not cause euphoria like some illegal stimulants, it can have a profoundly positive impact on mood and anxiety.
As mentioned above, initially Provigil was developed to treat narcolepsy and obstructive sleep apnea. It eliminates the effects of the chronic lack of sleep and drowsiness that occur as a result of the consequent shifts work. Unlike amphetamine, which causes euphoria and side effects in the form of hangover and addiction, Modafinil significantly improves concentration and performance without side effects. The drug is used in military and space missions.
What is Provigil used for?
Scientists suggest that the drug could be used to treat dependence on cocaine and some other addictive stimulants. The drug is able to cope with the withdrawal symptoms, but a positive result is not guaranteed and depends on a number of psycho-emotional factors.
Numerous clinical trials have confirmed that the drug reduces appetite and promotes intensive weight loss. Provigil also demonstrates outstanding results in the therapy of cognitive impairment, is used to improve memory, and eliminates excessive daytime fatigue and drowsiness that are caused by primary biliary cirrhosis.
Since 2004, Provigil tablets have been used to treat adolescents and children suffering from hyperactivity and attention deficit disorder. Provigil and its analogs are currently used to alleviate symptoms of multiple sclerosis such as neurological fatigue and depressive conditions.
Contraindications for Provigil
Use of the medicine is prohibited in the cases of individual intolerance or hypersensitivity to the components of the drug, vascular or cardiac diseases, phobias or nervous system disorders.
Provigil is contraindicated in pregnancy and during lactation. The medication should not be combined with alcoholic beverages and can significantly reduce the effectiveness of contraceptives. The drug is strictly prohibited for patients with cirrhosis and severe liver diseases.
For the treatment of drowsiness and narcolepsy, the drug should be used once a day in the morning in the dosage of 200–300 mg. In studies involving aircraft pilots, 600 mg of Provigil, divided into several receptions, allowed the pilots to maintain high accuracy, excellent reaction rates, and concentration for one and a half days.
Common Side Effects of Provigil
Provigil is considered a safer stimulant than amphetamine and even caffeine. The most common side effects that occur with an overdose of the drug are headache and nausea.
Increased sensitivity to the components of the drug can trigger dermatitis and a number of skin reactions. Rarely, the medication can cause shortness of breath, dyspeptic disorders, nasal congestion, the appearance of ulcers in the mouth and urticaria.
Provigil should not be used by children, despite the fact that the results of the studies demonstrated the relative safety of the drug for adolescents and children aged 9 to 17 years.